Endocrine Abstracts

Histamine is an important anorexic factor that suppresses food intake via hypothalamic H1 receptors and increases energy expenditure by stimulating lipolysis. Mice with targeted deletion of the key enzyme of histamine biosynthesis, histidine decarboxylase (HDC-KO), are unable to synthesize histamine. These animals display a metabolic phenotype with adult onset obesity, selective increase in visceral fat depots, impaired glucose tolerance and hyperleptinemia. To test the possib...

Central control of body weight involves coordinated regulation of food intake and energy metabolism. White (WAT) and brown (BAT) adipose tissue represent functionally distinct compartments of lipid storage and fuel consumption, respectively. Both adipose tissues are innervated by the sympathetic nervous system. Tyrosine hydroxylase positive fibers were found in between fat cells. To determine the extent to which the control of different fat compartments is provided by the same...

Background and aims: Dehydroepiandrosterone fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity. DHEA-FAEs function through hydrolysis of DHEA-FAEs into free DHEA and further metabolized to biologically active steroids. The lysosomal acid lipase (LAL) mediates the intracellular hydrolysis of cholesterol esters. This study aims to study the possible role of LAL on the hydrolys...

Background and aims: Dehydroepiandrosterone (DHEA) is an important prohormone and precursor of all sex steroids. DHEA fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity, which are exclusively transported in lipoproteins. In the circulation, DHEA is esterified in a reaction catalyzed by lecithin-cholesterol acyltransferase associated with HDL particles. The physiological role...

Sex Hormone binding globulin (SHBG) is a plasma steroid binding protein that is the major determinant androgen and estrogen access to target tissues. Several ligands of SHBG have been predicted by computational methods or discovered through basic research, they include pharmaceutical, natural plant extracts and anthropogenic endocrine disrupting compounds. In this study we characterized 3,4-Divanillyltetrahydrofuran (DVT), a non-steroidal ligand of SHBG, and Danazol, a synthet...

Background: Bone turnover is increased in active acromegaly. Despite normalization of bone turnover after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not bone mineral density (BMD) is correlated to vertebral fracture incidence. Trabecular and cortical bone are differentially affected by GH and IGF-1. The trabecular bone score (TBS) is related to bone microarchitecture and provides further information not captured by BMD measurement.<p...

Cytokines, including adhesion molecules, are a family of protein mediators that are important in transducing information between various cell types, were non-immune cells may also be important sources of certain cytokines.Aim: Aim of this study was to evaluate of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) in patients with non-immune nodular thyroid disease...

Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.Methods: A cohort study of 357 COVID-19 patients was conducted. Subjects were monitored until discharge or in-hospital de...

For all ERCUSYN investigatorsBackground: Patients with Cushing’s syndrome (CS) have an increased risk of developing venous thromboembolic complications. There is currently no standard practise for thromboprophylaxis in CS patients.Aim: To study the details of VTE in patients included in The European Registry on Cushing’s syndrome (ERCUSYN) and study various thromboprophylaxis protocols used among the centres where VTE&#14...

Introduction: A growth hormone-secreting pituitary adenoma (GH-PA) increases the risk of complications and death. It’s management is determined by MRI data and decrease of insulin-like growth factor-1 (IGF-1) during the octreotide suppression test (OST). Currently, there is evidence that MRI-T2-hypointensive somatotropinoma and high expression of somatostatin receptors type 2 (SSTR2) according to immunohistochemical analysis (IHC) predict high efficacy of somatostatin ana...